Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions

Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions

Blog Article

It is believed that human Influenza HA glycoprotein attaches to alpha2-6 linked sialic acids (SA) on cells, while liftmaster la500dc avian viruses bind to alpha2-3 linked sialic acids, therewith contributing to host tropism.Here, Liu et al.show that mixing low-affinity alpha2-3 SA with low amounts of high-affinity alpha2-6 SA increases binding and entry of human viruses and the converse for avian virus.This viqua-f4 shows that receptor recognition is not as strict as currently assumed and provides evidence that heteromultivalent interactions between human/avian HA and SA contributes to host adaptation.